Publications (lab members in bold) 2022 Tookman E, Junghans L, Kulkarni G, Ledermann R, Sáenz JP*, Newman DK*. (2021) Hopanoids confer robustness to physicochemical variability in the niche of the plant symbiont Bradyrhizobium diazoefficiens. Journal of Bacteriologyhttps://doi.org/10.1128/jb.00442-21 *co-corresponding
Czerniak T, Sáenz JP(2021). Lipid membranes modulate the activity of RNA through sequence-specific interactions.Proceedings of the National Academy of Science. V. 119 (4) https://doi.org/10.1073/pnas.2119235119
Thornburg Z, Bianchi DM, Brier TA, Gilbert BR, Earnest TM, Melo MCR, Safronova N, Sáenz JP, Cook AT, Wise KS, Hutchison CA, Smith HO, Glass JI, Luthey-Schulten Z. Fundamental behaviors emerge from simulations of a living minimal cell. Cell v. 185 (2): 345-360 https://doi.org/10.1016/j.cell.2021.12.025
Tookmanian E, Belin BJ,Sáenz JP, Newman DK (2021). The role of hopanoids in fortifying rhizobia against a changing climate.Environmental Microbiologyhttps://doi.org/10.1111/1462-2920.15594
Nsamela, A, Sharan P, Garcia-Zintun A, Heckel S, Chattopadhyay P, Wang L, Wittmann M, Gemming T,Sáenz JP, Simmchen J (2021). Effect of viscosity on microswimmers: a comparative study.Chem. Nano. Mat.https://doi.org/10.1002/cnma.202100119
2020 Chwastek G, Surma MA, Rizk S, Grosser D, Lavrynenko O, Rucinska M, Jambor H, Sáenz JP (2020) Principles of Membrane Adaptation Revealed Through Environmentally Induced Bacterial Lipidome Remodeling. Cell Reports v. 32 (12). https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31154-2
2015 Sáenz JP*, Grosser D, Bradley A, Lagny TJ, Broda M, Lavrynenko O, Simons K*. 2015. Hopanoids as functional analogues of cholesterol in bacterial membranes. Proceedings of the National Academy of Science. v. 112 (38): 11971-11976.https://doi.org/10.1073/pnas.1515607112 *co-corresponding Highlighted in Faculty Opinions Article Recommendations: https://facultyopinions.com/article/725777047
Stordeur C, Hofbauer H, Sáenz JP, Ernst, R. (2015) Homeostatic control of biological membranes by dedicated lipid and membrane packing sensors. Biological Chemistry, DOI: http://dx.doi.org/10.1515/hsz-2015-0130
2014 Stordeur C, Puth K, Sáenz JP, Ernst, R. (2014) Crosstalk of lipid and protein homeostasis to maintain membrane function. Biological Chemistry, v. 395 (3): 313-326.https://doi.org/10.1515/hsz-2013-0235
2012 Sáenz JP, Sezgin E, Schwille P, Simons K. (2012) Functional convergence of sterols and hopanoids in membrane ordering. Proceedings of the National Academy of Science v. 109 (35): 14236-14240.https://doi.org/10.1073/pnas.1212141109
Sáenz JP, Hopmans E, Henderson P, Charette M, Casciotti K, Schouten S, Sinninghe Damsté J, Eglinton TI. (2012) Distribution of anaerobic ammonia-oxidizing bacteria in a subterranean estuary. Marine Chemistry v. 136-137: 7-13. https://doi.org/10.1016/j.marchem.2012.04.004
Wakeham SG, Turich C, Schubotz F, Podlaska A, Li XN, Varela R, Astor Y, Sáenz JP, Rush D, Sinninghe Damsté J, Summons RE, Scranton MI, Taylor GT, Hinrichs K. (2012) Biomarkers, chemistry and microbiology show chemoautotrophy in a multilayer chemocline in the Cariaco Basin. Deep Sea Research I v. 63: 133-156. https://doi.org/10.1016/j.dsr.2012.01.005
Sáenz JP, Summons RE, Eglinton TI, Waterbury J. (2012) Hopanoids in marine cyanobacteria: probing their phylogenetic distribution and biological role. Geobiology v. 10 (4): 311-319. https://doi.org/10.1111/j.1472-4669.2012.00318.x
2011 Sáenz JP, Summons RE, Eglinton TI, Wakeham SG. (2011) New constraints on the provenance of hopanoids in the marine geologic record: Bacteriohopanepolyols in marine suboxic and anoxic environments. Organic Geochemistry v. 42: 1351-1362. https://doi.org/10.1016/j.orggeochem.2011.08.016
Sáenz JP, Summons RE, Eglinton TI. (2011) Abundance and structural diversity of bacteriohopanepolyols in suspended particulate matter along a river to ocean transect. Organic Geochemistry v. 42: 774-780. https://doi.org/10.1016/j.orggeochem.2011.05.006
2010 Sáenz JP. (2010) Exploring the Distribution and Physiological Roles of Bacterial Membrane Lipids in the Marine Environment. Ph.D. Thesis. MIT/WHOI, 2010-18https://dspace.mit.edu/handle/1721.1/59757
Sáenz JP. (2010) Hopanoid enrichment in a detergent resistant membrane fraction of Crocosphaera watsonii: Implications for bacterial lipid raft formation. Organic Geochemistry v. 41(8): 853-856. https://doi.org/10.1016/j.orggeochem.2010.05.005
Bradley AS, Pearson A, Sáenz JP, Marx CJ. (2010) Adenosylhopane: the first step in biosynthesis of hopanoid side chains. Organic Geochemistry v. 41(10): 1075-1081. https://doi.org/10.1016/j.orggeochem.2010.07.003
2009 Coolen MJL, Sáenz JP, Trowbridge N, Giosan L, Eglinton TI. (2009) DNA and lipid molecular stratigraphic records of haptophyte succession in the Black Sea during the Holocene. Earth and Planetary Science Letters v. 284 (3-4): 610-621. https://doi.org/10.1016/j.epsl.2009.05.029
2008 Pearson A, Leavitt WD, Sáenz JP, Summons RE,. Tam CM, and Close HG. (2008) Diversity of hopanoids and squalene-hopene cyclases across a tropical land-sea gradient. Environmental Microbiology v. 11 (5): 1208-1223. https://doi.org/10.1111/j.1462-2920.2008.01817.x
2004 Hill WG, Mathai JC, Gensure RH, Zeidel JD, Apodaca G, Sáenz JP, Kinne-Saffran E, Kinne R, Zeidel ML. (2004) Permeabilities of teleost and elasmobranch gill apical membranes: evidence that lipid bilayers alone do not account for barrier function. American Journal Of Physiology-Cell Physiology, v. 287 (1): C235-C242. https://doi.org/10.1152/ajpcell.00017.2004
2003 Sáenz JP, Kinne R, and Kinne-Saffran E. (2003) Determination of the purity of membrane fractions isolated from flounder (Pleuronectes Americanus) gills by a selective biotin exposure technique. Bulletin of the Mount Desert Island Biological Laboratory, v. 42: 85-88.
Hill WG, Mathai JC, Gensure R, Sáenz JP, Kinne-Saffran E, Zeidel ML, Kinne R. (2003) Studies of Osmoregulation in Teleosts and Elasmobranchs: Water and Solute Permeabilites of Apical Membranes Isolated From The Gills of Flounder (Pleuronectes Americanus) and Shark (Sqaulus acanthias). Bulletin of the Mount Desert Island Biological Laboratory, v. 42: 27-28.